Paper. Reis JAS, Ueta LZ, Bouso JC et al.. Journal of Psychopharmacology, 27 Oct 2026.
Tags: Review, Psilocybin, Ayahuasca, Mescaline.
Across 52 studies, population data showed no consistent link between psychedelic use and psychosis.
Controlled trials turned up one documented case of transient delusions. Emergency and toxicology data showed higher rates, and among the 34 case reports, 58% of individuals had personal or family psychiatric history.
How much weight it carries: Systematic review of 52 heterogeneous papers, 34 of them case reports; no denominator for naturalistic risk and trial data come from pre-screened samples. (Humans, Systematic review, Observational)
