Paper. Barnett BS, Anand A, Falcone T et al.. Psychedelic Medicine, 26 Dec 2025.
Tags: Human, LSD.
Three in four recreational MDMA users report a comedown, typically starting about a day later.
In a survey of 497 MDMA-experienced adults, 74.5% reported at least one episode of post-acute negative effects, with onset around 24 hours. A separate pair of studies on meditation plus drugs found alcohol (29%), cannabis (19%) and nicotine (16%) are combined with practice far more often than classic psychedelics (6%), with no consistent link to wellbeing in either direction.
How much weight it carries: Cross-sectional self-report from online panels; recall-dependent, self-selected, and cannot establish that the drugs caused the reported effects. (Humans, Survey, Observational, n = 497, Peer reviewed)
