Paper. Baker JJ, Kogan E, Ma S et al.. Nature Neuroscience, 15 Oct 2026.
Tags: Psilocybin.
Two mouse studies dissociated psilocybin's synaptic remodeling from its hallucination proxy.
In Nature Neuroscience, 5-HT2A signaling in layer 5 cortical pyramidal neurons was necessary and sufficient for psilocybin's synapse formation and pruning, yet dispensable for the head-twitch response. Separately, a PDE9 inhibitor blunted psilocybin's head twitch while the antidepressant-like effect and synaptogenesis signaling survived.
