A living systematic review, meta-analysis, and open data resource of trials of MDMA-assisted therapy for PTSD

Paper. Sevchik BL, Singleton SP, Lahey A et al.. Neuropsychopharmacology, 11 Oct 2026.

Tags: Meta-analysis, Review, MDMA, PTSD.

Weekly Science Digest, 10 Oct 2026 to 16 Oct 2026, finding 3: Two syntheses, two modest effect sizes

MDMA for PTSD pools to g = -0.71; psilocybin for alcohol use disorder to around SMD 0.5.

The MDMA living review covers 6 RCTs and 286 participants, all MAPS-sponsored, with response risk ratio 1.35 and remission 2.25. The alcohol meta-analysis found 6 trials and only 202 participants total, of which 3 were randomized.

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