Effects of psychedelic drug use on neurocognitive function and the psychological and social domains of quality of life: an international online study

Paper. Stadler F, Saelens J, Henter ID et al.. Frontiers in Psychiatry, 24 Sep 2026.

Tags: Human, Ketamine, Depression.

Weekly Science Digest, 10 Oct 2026 to 16 Oct 2026, finding 5: In brief

Online study of 759 people: recent psychedelic users scored lower on cognitive tasks, lifetime users showed no long-term decline

Weekly Science Digest, 3 Oct 2026 to 9 Oct 2026, finding 2: Most psilocybin use is happening outside the clinic

One in 14 US adults with a past-year depressive episode reported using psilocybin.

In the 2024 National Survey on Drug Use and Health, 7.3% of 6,793 people with a past-year major depressive episode had used psilocybin, and the study asks whether that tracks with skipping conventional care. RAND's 2025 survey adds parallel data on veterans' use and their views on VA policy.

How much weight it carries: Nationally representative cross-sectional survey; good for prevalence, cannot establish whether psilocybin use causes or follows changes in treatment seeking. (Humans, Survey, Observational, n = 6,793)

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