Pharmacological, clinical, and translational evidence for N,N-dimethyltryptamine, 5-methoxy-N,N-dimethyltryptamine, and zalsupindole: a systematic review

Paper. Collyer C, Le GH, Hassan M et al.. Progress in Neuro-psychopharmacology & Biological Psychiatry, 6 Oct 2026.

Tags: Animal, Review, DMT, 5-MeO-DMT, Depression, PTSD, Addiction, Eating disorders.

Weekly Science Digest, 3 Oct 2026 to 9 Oct 2026, finding 4: Two compound reviews worth reading for the caveats

A DT120 profile insists 100 micrograms of LSD is a psychedelic dose, not microdosing.

The drug profile calls the phase 2b anxiolytic signal credible after a single 100 µg dose without mandated psychotherapy, while rejecting the "microdose" and "modified release" framing used around it — controlled microdosing work has used 5-20 µg.

How much weight it carries: Narrative drug profile plus a systematic review of 51 publications; both summarise existing trials rather than adding data. (Review, Systematic review)

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