Paper. Fluyau D, Revadigar N, Kim P. Alcohol and Alcoholism, 20 Sep 2026.
Tags: Meta-analysis, Review, Psilocybin, Ketamine, Addiction.
Pooled across six trials, psilocybin's edge on drinking is real but moderate and short-lived.
Six trials totalling 202 patients, only three randomized, give standardized mean differences of roughly 0.4-0.5 for drinks per day, percent drinking days and heavy drinking days versus control. Within-group reductions held out to 28 weeks, but those have no comparator.
How much weight it carries: Pooled estimate from six trials, only three randomized, 202 patients total; adequate to size a short-term signal, not to establish durability. (Humans, Meta-analysis, Systematic review, RCT, Small sample, n = 202)
